ABSTRACT
To investigate characteristics of euthyroid sick syndrome [ESS] in children with diabetic ketoacidosis [DKA]. This retrospective study was carried out between May 2010 and April 2013 at the Pediatric Department of Shandong Provincial Hospital, Shandong University, Shandong, China. Diabetic ketoacidosis children were divided into 2 groups: euthyroidism [group one, n=30] and ESS [group 2, n=40]. C-peptide, glycosylated hemoglobin [HbA1c], bicarbonate, anion gap [AG], free triiodothyronine [FT3], free thyroxine [FT4], and thyrotropin [TSH] levels were measured before and after 7 days of insulin treatment. Daily blood glucose [BG] profiles were recorded. Glycosylated hemoglobin, AG, the mean daily BG, and fasting blood glucose levels were higher, and bicarbonate, FT3, FT4, and TSH levels were lower in group 2 than in group one [all p<0.05]. Free triiodothyronine [r=-0.593, p<0.001] and FT4 [r=-0.402, p=0.001] were negatively correlated with HbA1c. Free triiodothyronine [r=-0.438, p<0.001] and FT4 [r=-0.505, p<0.001] were negatively correlated with AG, and FT3 [r=0.503, p<0.001] and FT4 [r=0.448, p<0.001] were positively correlated with bicarbonate. Diabetic ketoacidosis children with ESS have poor diabetic control. Free thyroid hormones are associated with the severity of DKA
Subject(s)
Humans , Male , Female , Child , Diabetic Ketoacidosis , Retrospective Studies , Thyroid HormonesABSTRACT
Objective To explore the clinical characteristics and risk factors of newly diagnosed type 2 diabetic mellitus (T2DM) patients and to investigate the correlations among nonalcoholic fatty liver disease (NAFLD), hyperuricemia, neck circumference (NC) and carotid intima-media thickness (CIMT) in these patients. Methods The 85 patients were all within one year after diagnosis and they were hospitalized immediately after diagnosis. The clinical data including NC, waiit circumference (WC), waitt-hip ratio (WHR), and body mass index (BMI) were collected. The fasting insulin, fasting C-peptide, hemoglobin A1c, liver and renal function, phenotype of lipid and uric microalbumin were determined, and ultrasound examination of the liver and carotid artery was performed. Results The prevalence rates of NAFLD, hyperuricemia and increased CIMT were 57.6% (49/85), 16. 5% (14/85) and 29. 4% (25/85), respectively. Up to 88. 2% (75/85) of the patients had two or more metabolic abnormalities. Patients withNAFLD, hyperuricemia and increased NC had significantly more metabolic abnormalities compared with those without the corresponding conditions (P<0. 05). The BMI, NC, WC, alanine aminotransferase (ALT), and triglyceride (TG) were significantly different among different groups (all P < 0. 05). Multivariate unconditional logistic regression analysis showed that NC, WC, BMI, ALT, fasting C-peptide, and serum uric acid (SUA) were common risk factors of NAFLD and increased CIMT. Conclusion Mott newly diagnosed T2DM are concomitant with a variety of metabolic abnormalities. NAFLD, hyperuricemia, increased NC and CIMT are risk factors to each other. NC and SUA are also the common risk factors of NAFLD and increased CIMT.
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Objective To explore the feasibility of "immersion program" in French-taught surgical lessons,as to provide multiple educational methods and practical experiences for the application of bilingual education in clinical medicine.Methods Twenty-nine senior students of French-taught class were randomly divided into group A(n=15) and group B(n=14)."Immersion program" and "transitional bilingual education" were employed for group A and group B,respectively for the first half of teaching session,and "transitional bilingual education" and "immersion program" for the second half,respectively.The differences between the two bilingual education models were compared through quiz.Results In the prior 2 of the 4 quiz,the scores of French quiz and the total scores were much higher in "immersion program" group,and there were significant differences between the two groups(P0.05). Conclusion "Immersion program" helps to improve the ability of presentation,comprehension and application of French in the precondition of equal educational content,and it will be more beneficial when accessing the "immersion program" on the basis of "transitional bilingual education".
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Objective To investigate the value of endoscopy combined with laparoscopy in the treatment of colorectal polyps and polyp canceration.Methods Different combinations of endoscopic and laparoscopic procedures were employed and the clinical efficacies were compared.Results From January 2004 to September 2006,46 cases with colorectal polyp were treated with endoscopy combined with laparoscopy.Among them,5 cases(10.87%)underwent laparoscopic-assisted endoscopic polypectomy,30(65.22%)endoscopic-assisted laparoscopic resection,6(13.04%)synchronously endoscopic and laparoscopic resection.Five cases were performed further operation after endoscopic polypectomy.According to the pathological findings,21(45.7%)were proved to be polyp canceration,among which 6 were advanced carcinoma,and 3 were found metastasis to the lymph nodes.Among the 41 cases of laparoscopic resection,there was no conversion to an open surgery.Anastomotic leakage was found in 2 cases and anastomotic bleeding in 1.In the 5 cases of laparoscopic-assisted endoscopic polypectomy,no complication was observed.During the period of follow-up(1 to 21 months),no recurrence was detected.Conclusion Endoscopy combined with laparoscopy extends the safety and indications of endoscopic polypectomy,and is minimally invasive to the patients.It is an ideal procedure in the treatment of colorectal polyps and poly carceration.